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Tiny nerve zap study probes migraine pain mystery

NCT ID NCT06022848

Knowledge-focused Sponsor: Barts & The London NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small study looked at how occipital nerve stimulation (ONS) changes the way people with chronic migraine or cluster headache feel pain. Researchers used special tests and questionnaires to measure pain markers before and after ONS, and compared results to people having non-painful surgery or healthy volunteers. The goal was to understand how ONS affects pain processing, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

6 people

The number who actually took part.

Started

Sep 2019

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria Subject satisfies standard criteria in the study centre for ONS implantation and the NICE 452 criteria for intractable chronic migraine or cluster headache. Patients who have given their written informed consent. Patient is able and willing to comply with study procedures and follow up schedule. Participants will need a good understanding of the English Language and hence. This is a requirement not just for this research but also for the success of the interventions and the full understanding of QST. Patients undergoing surgery (non-painful complaint) 'dilatation and curettage' (D\&C). Exclusion criteria * Any inclusion criteria not met * Female patients of childbearing age who is or plans on becoming pregnant during the course of the study * Patients with diabetes * Patients known to have a condition that in the investigator's judgment precludes participation in the study. * Patients who have received an investigational drug or have used an investigational device in the 30 days preceding to study entry

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Conditions

The condition(s) this trial relates to.

cluster headache syndrome migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Migraines

Contacts and locations

Locations

  • Barts health NHS Trust

    London, EC1A7BE, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.