Can a Weight-Loss drug stop obesity before it starts? new trial aims to find out

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to M 25 at screening * BMI \>/= 25 to \< 30 kg/m\^2 * Family history of obesity defined as one biological parent with severe obesity (BMI \>/= 35) and/or two biological parents with obesity (BMI \>/=30). Parental obesity status will be confirmed by obtaining a release of information to review and electronic health record. Exclusion Criteria: * Tanner stage 1-4 * Diabetes (type 1 or 2) * Current or recent (\<6 months prior to screening) use of anti-obesity medication(s) or other weight-altering medication(s) (e.g. atypical anti-psychotics, attention deficit hyperactivity disorder (ADHD) stimulant) * Previous bariatric surgery * Current or recent (\<6 months prior to screening) use of medication(s) to treat insulin resistance * Recent initiation (\<3 months prior to screening) of anti-hypertensive or lipid medication(s) * History of glaucoma * Current or recent (\<14 days prior to screening) use of monoamine oxidase inhibitor * Known hypersensitivity to sympathomimetic amines * History of treatment with growth hormone * Patient Health Questionnaire-9 (PHQ-9) score of \>/= 15 at screening * Eating disorder symptoms within 6 months and/or any past medical diagnosis of eating disorder * Major psychiatric disorder * Unstable clinically-diagnosed depression * History of suicide attempt * Suicidal ideation of type 4 or 5 on the Columbia-Suicide Severity Rating Scale (C-SSRS) at any time during the study * Current pregnancy or breastfeeding * Plans to become pregnant * If sexually active, refusal to use 2 forms of birth control * Tobacco use * Alanine transaminase (ALT) or aspartate transaminase (AST) \>/= 2.5 times the upper limit of normal * Bicarbonate 18 mmol/L * Creatinine \> 1.2 mg/dL * Creatinine clearance \<50 mL/min (Schwartz formula) * History of seizures * Uncontrolled hypertension * History of structural heart defect * History of clinically significant arrhythmia * Diagnosed monogenic obesity * History of cholelithiasis * History of nephrolithiasis * Hyperthyroidism * Untreated thyroid disorder