New brush and slurry combo could save failing dental implants
NCT ID NCT06695559
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a non-surgical treatment for peri-implantitis, a gum infection around dental implants. Forty adults with mild bone loss received either a cleaning with a special chitosan brush alone or with an added tetracycline antibiotic slurry. The goal was to see if the antibiotic slurry improves healing and reduces pocket depth around the implant.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- chitosan brush and tetracycline slurry
- What this could lead to
- If successful, this could offer a better non-surgical option to control peri-implantitis and reduce the need for more invasive procedures.
- What could go wrong
- This is a small, early-phase trial with only 40 participants, so results may not apply widely. The treatment is for mild cases and may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
40 people
The number who actually took part.
- Started
-
Feb 2024
- Finished
-
May 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Peri-implantitis defined as periimplant bone loss ≥ 3 mm on periapical x-rays distally, mesially or both and with Probing Pocket Depth (PPD) ≥6 mm. * Peri-implantitis as defined above on an implant that has been in function for more than 12 months prior to study start. * Above 18 years of age. * Eligible for treatment in an outpatient dental clinic (ie, American Society of Anesthesiologists classification I and II). * Had full-mouth plaque scores \< 20% prior to final inclusion. * Had at least one implant with a loading time of ≥ 12 months prior to baseline. * Signed Informed Consent obtained prior to start. * Psychological appropriateness * Consent to complete all follow-up visits. * Patients diagnosed with periodontal disease must have undergone causative treatment and be re-evaluated Exclusion Criteria: * Peri-implant bone loss \> 6 mm on periapical x-rays * Cemented supraconstructions and/or screw retained supraconstructions that for technical reasons makes it impossible to access implant for clinical measurements. * Technical complications which according to the examiners judgement has contributed to the disease state and not possible to resolve prior to final inclusion. * Mobile implant. * Implants previously treated for peri-implantitis with grafting materials. * Receiving medications known to induce mucosal hyperplasia. * Uncontrolled diabetes (HbA1c \> 7). * Receiving systemic antibiotics \< 3 months prior to inclusion. * Pregnant or lactating. * Any condition or current treatment for any condition, which in the opinion of the investigator and/or consulting physician, may constitute an unwarranted risk. * Presence of psychological characteristics, such as inappropriate attitude or motivation, which will influence treatment execution and treatment outcome. * Unwillingness to undergo treatment. * If, in the medical opinion of the therapist, conditions are such that dental implants are deemed failing. * Ongoing or previous radiotherapy to the head-neck region. * Ongoing or previous chemotherapy. * Systemic long-term corticosteroid treatment. * Patients medicating with warfarin products or similar
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Aristotle University of Thessaloniki
Thessaloniki, 54124, Greece
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Laser shows promise for treating implant gum disease
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