New brush and slurry combo could save failing dental implants

NCT ID NCT06695559

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a non-surgical treatment for peri-implantitis, a gum infection around dental implants. Forty adults with mild bone loss received either a cleaning with a special chitosan brush alone or with an added tetracycline antibiotic slurry. The goal was to see if the antibiotic slurry improves healing and reduces pocket depth around the implant.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
chitosan brush and tetracycline slurry
What this could lead to
If successful, this could offer a better non-surgical option to control peri-implantitis and reduce the need for more invasive procedures.
What could go wrong
This is a small, early-phase trial with only 40 participants, so results may not apply widely. The treatment is for mild cases and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

40 people

The number who actually took part.

Started

Feb 2024

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Peri-implantitis defined as periimplant bone loss ≥ 3 mm on periapical x-rays distally, mesially or both and with Probing Pocket Depth (PPD) ≥6 mm. * Peri-implantitis as defined above on an implant that has been in function for more than 12 months prior to study start. * Above 18 years of age. * Eligible for treatment in an outpatient dental clinic (ie, American Society of Anesthesiologists classification I and II). * Had full-mouth plaque scores \< 20% prior to final inclusion. * Had at least one implant with a loading time of ≥ 12 months prior to baseline. * Signed Informed Consent obtained prior to start. * Psychological appropriateness * Consent to complete all follow-up visits. * Patients diagnosed with periodontal disease must have undergone causative treatment and be re-evaluated Exclusion Criteria: * Peri-implant bone loss \> 6 mm on periapical x-rays * Cemented supraconstructions and/or screw retained supraconstructions that for technical reasons makes it impossible to access implant for clinical measurements. * Technical complications which according to the examiners judgement has contributed to the disease state and not possible to resolve prior to final inclusion. * Mobile implant. * Implants previously treated for peri-implantitis with grafting materials. * Receiving medications known to induce mucosal hyperplasia. * Uncontrolled diabetes (HbA1c \> 7). * Receiving systemic antibiotics \< 3 months prior to inclusion. * Pregnant or lactating. * Any condition or current treatment for any condition, which in the opinion of the investigator and/or consulting physician, may constitute an unwarranted risk. * Presence of psychological characteristics, such as inappropriate attitude or motivation, which will influence treatment execution and treatment outcome. * Unwillingness to undergo treatment. * If, in the medical opinion of the therapist, conditions are such that dental implants are deemed failing. * Ongoing or previous radiotherapy to the head-neck region. * Ongoing or previous chemotherapy. * Systemic long-term corticosteroid treatment. * Patients medicating with warfarin products or similar

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Aristotle University of Thessaloniki

    Thessaloniki, 54124, Greece

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