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Laser shows promise for treating implant gum disease

NCT ID NCT07524153

Disease control Sponsor: Kırıkkale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether using a 940 nm diode laser along with standard deep cleaning helps treat peri-implantitis, a gum infection around dental implants. 39 adults with infected implants were split into three groups: cleaning alone, laser alone, or both. Researchers measured gum health and levels of a protein called S100A8, which signals inflammation. The goal was to see if the laser reduces infection and inflammation better than cleaning alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
940 nm diode laser
What this could lead to
If successful, this could point toward a more effective treatment for peri-implantitis, reducing inflammation and improving gum health around dental implants.
What could go wrong
This is a small, completed study with only 39 participants, so results may not apply to everyone. The laser is an add-on, not a standalone cure, and long-term benefits are unclear.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

39 people

The number who actually took part.

Started

Jan 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of systemically healthy, non-smoking individuals aged 30-65 years who have at least one functional dental implant diagnosed with peri-implantitis (probing depth ≥ 6 mm, no clinical mobility). Participants are selected from patients admitted to the Kırıkkale University Faculty of Dentistry, Department of Periodontology for routine follow-up or treatment.

Ages

30 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged 30-65 years. * Presence of at least one functional dental implant with no clinical mobility * Diagnosis of peri-implantitis with a probing depth (PD) of ≥ 6 mm. * Ability to provide informed consent and attend follow-up visits. Exclusion Criteria: * Systemic diseases that may interfere with wound healing (e.g., uncontrolled diabetes). * History of radiation or chemotherapy. * Pregnancy or lactation. * Smoking or alcohol consumption. * Parafunctional habits (e.g., bruxism). * Use of systemic antibiotics within the last 6 months. * Periodontal or peri-implant treatment in the relevant area within the last 3 months.

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Conditions

The condition(s) this trial relates to.

Inflammation Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Biomarkers Calprotectin Periimplant diseases S100A8

Contacts and locations

Locations

  • Kırıkkale University, Faculty of Dentistry

    Kirikkale, Kırıkkale, 71100, Turkey (Türkiye)

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