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Could a gentle zap to the neck ease your jaw pain?

NCT ID NCT06802445

Symptom relief Sponsor: Toros University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a non-invasive device that stimulates the vagus nerve, combined with self-care exercises, can reduce jaw and neck pain in people with temporomandibular disorders (TMD). 48 adults with jaw muscle pain participated. They received either real or placebo nerve stimulation plus a home exercise program. The goal was to see if the combination improves pain, jaw movement, and muscle function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-invasive vagal nerve stimulation
What this could lead to
If it works, this could offer a drug-free way to reduce jaw and neck pain in people with jaw joint disorders.
What could go wrong
This is a small, early-stage study with only 48 participants. The results may not apply to everyone, and the benefit over placebo might be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

48 people

The number who actually took part.

Started

Oct 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * between the ages of 18-45, * Diagnosed with myogenic TMDs according to TMD-DC Axis I and II criteria, * Pain intensity of 3 or more during rest and/or chewing according to the Visual Analogue Scale, * Volunteered to participate in the study and signed the informed consent form, * Individuals who do not have communication difficulties and whose native language is Turkish will be included in the study. Exclusion Criteria: * Diagnosed with arthrogenic or mixed type TMDs, * Severe psychiatric illness such as schizophrenia, * Previous vagal nerve stimulation or history of vagotomy, * Have extensive joint damage affecting the jaw, head, neck and shoulder areas, have a history of major trauma, fracture or surgery to these body parts, or are undergoing radiotherapy, * Diagnosed with cervical disc herniation, cervical radiculopathy or cervical myelopathy, * History of cardiac disease and being treated for cardiac problems, * Active implant users such as pacemakers, defibrillators, neurostimulators, cochlear implants and ventricular shunts, * Failure to understand the study protocol * Have a history of progressive neurological diseases (such as Parkinson's disease, MS, ALS, epilepsy, Alzheimer's disease) * Acute tinnitus * Skin problems such as dermatitis, infection, psoriasis, urticaria, acne or eczema at the stimulation site, * Has any anatomical abnormality that prevents successful placement of the ear electrode, * and reporting acute tinnitus, * Pregnant subjects will be excluded from the study

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Conditions

The condition(s) this trial relates to.

myofascial pain syndrome Pain temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular disorders (TMD)

Contacts and locations

Locations

  • Toros University 45 Evler Campus

    Mersin, 33140, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.