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Which breathing aid works best after extubation? new study compares NIV and HFNC

NCT ID NCT07630766

Disease control Sponsor: Benha University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 102 adults in the intensive care unit who were at high risk of needing a breathing tube again after it was removed. Researchers compared two types of breathing support: noninvasive ventilation (a mask that helps push air into the lungs) and high-flow nasal cannula (warm, moist air delivered through the nose). The goal was to see which method better prevents the need to put the breathing tube back in. The study found which approach led to fewer reinsertions and better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

102 people

The number who actually took part.

Started

Jul 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

inclusion criteria 1. Age ≥18 years. 2. Received invasive mechanical ventilation for at least 24 hours. 3. Considered ready for planned extubation after successful completion of a spontaneous breathing trial. 4. High risk of extubation failure, defined by the presence of at least four of the following risk factors: Age \>65 years. APACHE II score \>12 on the day of extubation. Body mass index \>30 kg/m². Inadequate secretion management. Difficult or prolonged weaning. Two or more comorbidities. Acute heart failure requiring mechanical ventilation. Moderate-to-severe chronic obstructive pulmonary disease. Airway patency problems. Prolonged mechanical ventilation. Hypercapnia at the end of the spontaneous breathing trial. Exclusion Criteria: 1. Age \<18 years. 2. Presence of a tracheostomy. 3. Accidental extubation. 4. Self-extubation. 5. Contraindication to noninvasive ventilation.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extubation failure

Contacts and locations

Locations

  • Benha University Hospital

    Banhā, Qalyubia Governorate, 13511, Egypt

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