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Nerve stretching may ease Long-Term ankle pain

NCT ID NCT05090423

Symptom relief Sponsor: National Yang Ming Chiao Tung University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether adding nerve mobilization exercises to standard balance training can improve pain, movement, and function in people with chronic ankle instability. Thirty-six adults with a history of ankle sprains and ongoing instability participated. The results could help develop better rehabilitation strategies for this common condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
neurodynamic intervention (nerve mobilization exercises)
What this could lead to
If it works, this could point toward a better way to manage chronic ankle pain and instability without surgery or medication.
What could go wrong
This is a small, early-stage study with only 36 participants. Results may not apply to everyone, and the added benefit of nerve exercises over balance training alone is still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Jan 2022

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. History of at least two ankle sprains in the same leg, of which the first sprain is more than one year 2. Leading to at least one interrupted day of desired physical activity 3. The Cumberland Ankle Instability Tool (CAIT) ≦ 24 4. Slump test in ankle plantar flexion with inversion: positive Exclusion Criteria: 1. Pregnancy 2. Surgical treatments 3. Previous fractures in either lower extremity 4. Any concomitant lower extremity pathology, for example, vascular disease, osteoarthritis and rheumatoid arthritis 5. Significant pain or injury to the lumbar or cervical spine 6. Regular use of medication: anti-inflammatory drugs, painkiller, steroid or muscle relaxants 7. Previous manual therapy or exercise interventions received on the lower extremity within the previous 3 months

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Conditions

The condition(s) this trial relates to.

ankle injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankle sprains

Contacts and locations

Locations

  • National Yang Ming University

    Taipei, 11221, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.