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Could a common supplement help teeth grow their own roots?

NCT ID NCT03451435

Disease control Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tested whether N-acetyl cysteine (NAC) could help stem cells in damaged teeth grow roots to full maturity. The study planned to enroll up to 18 people with immature, infected teeth, but was terminated early with only 7 participants. Researchers used NAC as a final rinse before inducing bleeding during a standard root-rebuilding procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
N-acetyl cysteine
What this could lead to
If it works, this could point toward a better way to help immature teeth finish growing roots after infection.
What could go wrong
This was a very early, small trial that was terminated early, so results are limited. The approach may not work better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

7 people

The number who actually took part.

Started

Jun 2018

Finished

Apr 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 18 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Inclusion criteria include the following: 1. Subjects will be self and parent-reported as healthy individuals with no significant medical issues. 2. Radiographic assessment will determine that root(s) have not grown to completion 2\) Vitality tests (cold testing with Endo ice and Electric pulp testing) will determine the tooth to be necrotic 3) Palpation and percussion tests may or may not be positive 4) Probings will be within 1-5mm 5) Patient will commit to coming to 2-3 treatment appointments lasting 1-3 hours each. Thereafter, patient will commit to come for followup recall appointments 6 and 12 months following last treatment appointment. 6\) Patient must be able to tolerate sitting in a dental chair for 1-3 hours. 7) Patient will be in the age range of 6 to 18 years Exclusion Criteria: * Exclusion criteria include patients who cannot tolerate sitting in a dental chair due to anxiety for 1-2 hours.

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Conditions

The condition(s) this trial relates to.

dental pulp disorder dental pulp necrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endodontic disease

Contacts and locations

Locations

  • University of California, Los Angeles Dept of Graduate Endodontics

    Los Angeles, California, 90095, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.