Could a common supplement help teeth grow their own roots?
NCT ID NCT03451435
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tested whether N-acetyl cysteine (NAC) could help stem cells in damaged teeth grow roots to full maturity. The study planned to enroll up to 18 people with immature, infected teeth, but was terminated early with only 7 participants. Researchers used NAC as a final rinse before inducing bleeding during a standard root-rebuilding procedure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- N-acetyl cysteine
- What this could lead to
- If it works, this could point toward a better way to help immature teeth finish growing roots after infection.
- What could go wrong
- This was a very early, small trial that was terminated early, so results are limited. The approach may not work better than standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of California, Los Angeles Dept of Graduate Endodontics
Los Angeles, California, 90095, United States
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