Can a simple supplement boost fertility in PCOS? new study tests Myo-Inositol against combo therapy
NCT ID NCT07323589
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 120 overweight women with PCOS trying to conceive naturally. Half took myo-inositol alone, the other half took myo-inositol plus metformin for six months. The goal was to see which approach led to more confirmed pregnancies and had fewer side effects. The results help doctors choose the best treatment for improving fertility in PCOS.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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120 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Oct 2025
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 35 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women aged 20 to 35 years * BMI ≥25 kg/m² * Fulfilled at least two of the three Rotterdam criteria for PCOS * Attempting to conceive naturally * No use of hormonal drugs or insulin-sensitizers in the past three months Exclusion Criteria: * Endocrine disorders (e.g., diabetes, thyroid dysfunction) * Hepatic impairment * Kidney disease * Gastrointestinal or malabsorption issues (IBS, IBD, celiac disease) * Known allergies to metformin or inositol * Pregnant or breastfeeding
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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PAEC general hospital
Islamabad, Isb, 440000, Pakistan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a supplement duo quiet PCOS-Linked inflammation?
- Steak solution? lean beef may tame blood sugar in teens with PCOS
- Can diet plus inositol or metformin tame insulin resistance in PCOS?
- Can a gut microbiome transplant boost fertility in PCOS?
- A simple blood test may flag hidden insulin problems in PCOS
- Can tracking PCOS over time unlock better care?