New Light-Based imaging could spot hidden muscle problems
NCT ID NCT07347535
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new, non-invasive imaging method (multispectral optoacoustic tomography) to measure oxygen levels in leg muscles during exercise. Researchers will compare results from endurance athletes, strength athletes, healthy controls, and people with peripheral arterial disease (PAD). The goal is to see if this technique can detect differences in muscle oxygen and how it relates to standard exercise tests. About 60 adults will participate.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study will include adult participants aged 18 to 75 years, representing different levels of physical activity and vascular health status. A total of approximately 60 participants will be recruited, divided into six cohorts of about ten individuals each. Cohort Description: * Young endurance athletes (≥ 3 times per week, ≥ 60 minutes per session) Examples: running, cycling, swimming * Young strength athletes (≥ 3 times per week, ≥ 60 minutes) No additional endurance training * Young healthy controls Less than 2 times per week and \< 30 minutes of physical activity No known vascular or muscular diseases * Patients with peripheral arterial disease (PAD) Diagnosed with PAD, Fontaine stage I, IIa or IIb * Older inactive controls Age above 55 years, no regular physical activity, no pAVK * Patients with PAD (Fontaine stage I, IIa or IIb, who participate in structured walking training
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years (adults capable of giving consent) * Capacity to consent. The subjects are able to understand the information provided and give their written consent. * Belonging to one of the following cohorts: * Endurance athletes: at least 3× per week ≥ 60 minutes of intensive endurance training (e.g., running, cycling, swimming) * Strength athletes: at least 3× per week ≥ 60 minutes of intensive strength training without additional endurance training * Healthy control subjects: less than 2× per week \< 30 minutes of physical activity, no known vascular diseases * PAD patients: diagnosed peripheral arterial occlusive disease in Fontaine stage I or IIa Women of childbearing age with or without contraception may participate, as there are no risks of harm to the fetus. * Consent to pseudonymized data collection and storage in accordance with the GDPR. Exclusion Criteria: * Age over 75 years * Minors (Age \< 18) * safety concerns on the part of the study physician, e.g., in the case of of: physical, mental or psychiatric illnesses, acute or chronic conditions that could jeopardise safety or data quality * Taking medications that could affect physical performance or physiological measurements (e.g., heart rate, oxygen uptake). * Pregnancy with known risks or complications (participation is possible in principle, but subject to individual medical review). * Refusal to participate or lack of informed consent.
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Conditions
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