Vaping vs. smoking: new study scans blood vessel damage in real time
NCT ID NCT05271578
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study used MRI scans and blood tests to see how a single use of an e-cigarette (with or without nicotine) or a tobacco cigarette affects blood vessel function and inflammation. 55 current smokers and vapers were compared to a group of non-smokers/non-vapers. The goal was to understand the immediate physical effects of these products, not to test a treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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55 people
The number who actually took part.
- Started
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Jun 2022
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * BMI: 18.5 to 30 * Current users of electronic cigarettes or tobacco cigarettes with a use history of six months or greater. Exclusion Criteria: * Cancer * HIV * Mental illness in which the participant is not of proper cognizance * Overt cardio- or neurovascular disease (prior heart attack, stroke, transient ischemic attacks) * Serious arrhythmias * Bronchospastic disease * Upper respiratory tract infection within the past six weeks * Medication affecting vascular function * Antibiotics * Magnetic resonance imaging contraindications (metallic implants/intraocular foreign bodies, claustrophobia, cardiac/cochlear implantable electronic devices, etc.)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.