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Can a mouth rinse stop cavities? small study puts rinses to the test

NCT ID NCT04033263

Knowledge-focused Sponsor: University of Bern Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested three mouth rinses—plain water, a fluoride rinse, and one with plant extracts—to see how well they protect teeth from cavities and erosion. Twelve healthy adults used each rinse for five days while wearing special trays with tooth and dentin samples. The goal was to measure mineral loss and identify protective proteins in saliva.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mouth rinses (water, Elmex Erosion Protection, fluoride mouth rinse)
What this could lead to
If successful, this could point toward better mouth rinses for preventing cavities and tooth erosion.
What could go wrong
This is a very small, early study with only 12 healthy adults, so results may not apply to everyone. It measures short-term effects on tooth slabs, not real-world cavity prevention.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Nov 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants will be healthy young adults of both sexes, with normal salivary flow, with no cavitated caries lesions, no gingivitis or periodontal disease, no severe erosive tooth wear, and no other serious general or oral conditions. * Participants will have signed an informed consent form. Exclusion Criteria: * Presenting oral diseases or conditions, such as untreated cavitated caries lesions, gingivitis or periodontitis, severe erosive tooth wear, etc. * Participants who are under orthodontic treatment (wearing braces), * Contraindications to the mouth rinses under study, e.g. known hypersensitivity or allergy to the investigational product, * Participants using drugs that cause hyposalivation, * Women who are pregnant or breast feeding, * Intention to become pregnant during the course of the study, * Individuals suffering from clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.), * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant, * Participation in another study with investigational drug within the 30 days preceding and during the present study, * Enrolment of the investigator, his/her family members, employees and other dependent persons, * Specific exclusions for the disease under study, * Specific concomitant therapy washout requirements prior to and/or during study participation

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Conditions

The condition(s) this trial relates to.

dental caries tooth erosion, non-bacterial

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries Dental erosion

Contacts and locations

Locations

  • Univesity of Bern (Klinik für Zahnerhaltung, Präventiv- und Kinderzahnmedizin)

    Bern, Canton of Bern, 3010, Switzerland

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