Stroke drug trial halted after just two patients
NCT ID NCT06107725
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study aimed to see if the antibiotic minocycline could improve outcomes after a stroke. Participants were to receive either standard care plus minocycline pills for five days, or standard care alone. However, the trial was stopped early after enrolling only 2 people, so no meaningful results were obtained.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Minocycline (an antibiotic) taken as 200 mg pills once daily for five days
- What this could lead to
- If it worked, minocycline might offer a simple, cheap way to improve recovery and reduce death after a stroke.
- What could go wrong
- The trial was terminated after enrolling only 2 people, so no reliable conclusions can be drawn. Minocycline's benefit for stroke remains unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
-
2 people
The number who actually took part.
- Started
-
Nov 2023
- Finished
-
May 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age \>/=18 2. Acute onset neurological deficit consistent with acute ischemic stroke or on imaging consistent with acute ischemia as defined by WHO (World Health Organization) guidelines 3. Acute onset of neurological deficits with intracerebral Hemorrhage on imaging consistent with intracerebral bleed 4. The onset of symptoms less than 24 hours 5. Measurable neurological deficit using NIHSS (National Institutes of Health Stroke Scale ) Exclusion Criteria: 1. Clinically not suspect stroke. 2. Allergic to the Tetracycline group of medications or Intolerance to Minocycline 3. Pregnancy or suspected pregnancy 4. Previous history of intolerance to minocycline 5. Acute or chronic renal failure 6. Any patients with contraindications to undergo CT/ MRI 7. Life expectancy less than one year or severe co-morbidities or comfort measure only (CMO) on admission 8. Pre-existing infectious disease requiring antibiotics 9. Inability to tolerate enteral medications/feeds 10. Patient/ family refusal
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Maimonides Medical Center
Brooklyn, New York, 11219, United States
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