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Hidden brain fog in liver disease: new study sheds light

NCT ID NCT04807803

Knowledge-focused Sponsor: IHU Strasbourg Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 82 adults with cirrhosis and portal hypertension (high blood pressure in the liver) to find out how many have minimal hepatic encephalopathy (MHE) — a mild form of brain fog that can affect thinking. Researchers used simple blood tests and thinking exercises like naming animals and connecting numbers to check for MHE. The goal was to better understand how liver problems and blood vessel changes in the belly relate to subtle brain changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

82 people

The number who actually took part.

Started

Mar 2021

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with cirrhosis and portal hypertension older than 18 old * Patient who underwent a CT scan or MRI in the last 3 months * The Mini-Mental State (MMS) test \>25. * Patient capable of receiving and understanding information relating to the study and of giving his written informed consent. * Patient affiliated to the French social security system Exclusion Criteria: * Cirrhotic patient with overt HE or history of persistent or recurrent HE. * Hepatocellular carcinoma beyond Milan criteria. * Portal vein thrombosis. * Previous transjugular intrahepatic portosystemic shunt (TIPS) or surgical shunt. * Presence of neurological or psychiatric disorder. * Patient with treatment by benzodiazepines or opioid substitution. * Pregnant or nursing women * Patient in exclusion period of a previous study * Patient under guardianship, trusteeship or the protection of justice or incapable of giving their own informed consent

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver Fibrosis portal hypertension Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cirrhosis Portal hypertension

Contacts and locations

Locations

  • Service d'Hépato-Gastroentérologie, Hôpitaux Civils

    Colmar, 68024, France

  • Service d'Hépato-gastroentérologie, NHC

    Strasbourg, 67000, France

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