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Can a gentler anesthesia protect older brains after surgery?

NCT ID NCT07424729

Knowledge-focused Sponsor: Ankara Etlik City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 90 older adults (ages 65-85) having surgery under minimal-flow anesthesia. Researchers measured changes in thinking and memory using a simple test before and after surgery. The goal was to see if shorter surgery and this type of anesthesia might lower the risk of postoperative cognitive problems.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
minimal-flow anesthesia
What this could lead to
If successful, this could help identify ways to reduce memory and thinking problems after surgery in older adults.
What could go wrong
This is a small, completed observational study with 90 participants, so results may not apply to all older patients or surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Oct 2025

Finished

Mar 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:Inclusion Criteria: * Patients aged between 65 and 85 years * ASA physical status I-III * Scheduled for elective surgery under general anesthesia in general surgery or otorhinolaryngology operating rooms * Planned to receive minimal flow general anesthesia * Preoperative Mini-Mental State Examination performed * Able to provide informed consent Exclusion Criteria: * Age outside the specified range * ASA physical status IV or higher * Severe comorbid disease affecting perioperative stability * Surgery performed under regional anesthesia * History of alcohol, drug, or substance abuse * Significant visual or hearing impairment interfering with cognitive testing * Refusal to participate * Known neurological or psychiatric disorders * Preoperative MMSE score below 24 * Perioperative hemodynamic instability * Illiteracy preventing completion of cognitive tests * Postoperative admission to intensive care unit Exclusion Criteria: \-

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Conditions

The condition(s) this trial relates to.

Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative cognitive dysfunction

Contacts and locations

Locations

  • Ankara Etlik City Hospital

    Yenimahalle, Ankara, 06170, Turkey (Türkiye)

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Other studies related to the condition(s) this trial covers.