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Heart drug showdown: which works best after bypass?

NCT ID NCT07144267

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two drugs, milrinone and epinephrine, to treat right heart dysfunction that can occur after cardiac surgery. The trial will enroll 102 adults undergoing heart surgery with a heart-lung machine. The goal is to see which drug better improves right heart function right after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
milrinone and epinephrine
What this could lead to
If this trial succeeds, it could show which drug is better at helping the right side of the heart recover after heart surgery, potentially improving patient outcomes.
What could go wrong
This is a small, early-stage trial with only 102 participants, so results may not apply to everyone. Both drugs have known side effects like arrhythmias.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 102 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status II \& III * Age between 18 and 70 years * Both Gender * Body mass index less than 40 kg/m2 * Ejection fraction of \>40% * Tricuspid annular plane systolic excursion (TAPSE) \< 1.7cm Exclusion Criteria: * Patient refusal. * Preoperative RV impairment * Pulmonary hypertension (estimated pulmonary artery systolic pressure \> 50 mmHg) * Patients with any contraindications to Transesophageal echocardiography (TEE) * Redo or Re-exploration surgery * Patients with chronic kidney disease (serum creatinine \> 1.5 mg/ dl) * Patients with chronic liver disease (child pugh B and C)

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Conditions

The condition(s) this trial relates to.

postoperative ventricular dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac anaesthesia Cardiopulmonary bypass

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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