Microwave zaps wisdom teeth before they grow
NCT ID NCT05374993
First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time
Summary
Researchers are testing a device called the Zero3 System that uses microwave energy to destroy early wisdom tooth buds in children ages 8 to 12. The goal is to prevent wisdom teeth from ever forming, which could avoid future surgery. Participants have scans to find tooth buds that have not yet hardened, then receive the procedure if eligible. They visit the dentist at 7, 30, and 90 days to check healing and whether the buds are gone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A microwave device called the Zero3 System that heats and destroys early wisdom tooth buds
- What this could lead to
- If it works, children could avoid wisdom tooth surgery later by having the buds treated early, before the teeth form.
- What could go wrong
- This is a first-in-human study with 35 children, so safety and effectiveness are still unknown. The procedure could cause pain, infection, or damage nearby tissue, and the buds might still grow.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 35 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Nov 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subject is between 8 and 12 years of age 2. Subject has radiographic evidence of at least one mandibular 3rd molar tooth bud Exclusion Criteria: 1. Subject use of articaine is contraindicated (known hypersensitive to products containing sulfites). 2. Subject has any condition which, in the opinion of the Investigator, would prevent adequate performance of the procedure or affect the health and/or safety of the subject.-
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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Other studies related to the condition(s) this trial covers.
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