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Braces users may get a new weapon against ugly white spots

NCT ID NCT07244991

Disease control Sponsor: Cardenal Herrera University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a daily cream called MI Paste Plus can reduce cavity-causing bacteria and prevent white spots on teeth in people with braces. Two hundred participants will apply the cream nightly for three months. Researchers will measure bacteria levels and check for new white spots.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MI Paste Plus (a dental cream with casein phosphopeptide-amorphous calcium phosphate and sodium fluoride)
What this could lead to
If it works, this could give people with braces a simple way to prevent white spots and cavities during treatment.
What could go wrong
This is a small, early-stage trial with only 200 people. The effect may be small or not last long, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

5 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 5 and 45 years. * Indication for fixed orthodontic treatment, either with fixed auxiliary appliances (including orthopedic devices) or brackets with or without auxiliary components. * General good health with no systemic diseases affecting oral health. Exclusion Criteria: * Advanced white-spot lesions with untreated dentin involvement. * Presence of active untreated dental caries at baseline. * Antibiotic therapy within the previous two months. * Previous diagnosis of molar-incisor hypomineralization (MIH). * History of immunosuppression. * Iron-deficiency anemia or other clinically relevant hematological disorders. * Parafunctional habits such as lip sucking or finger sucking. * Use of any type of dental prosthesis. * Smoking or tobacco use. * Documented allergy to nickel. * Requirement for orthodontic treatment using removable appliances or clear aligners.

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Conditions

The condition(s) this trial relates to.

dental caries Tooth Demineralization tooth resorption enamel caries prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries Orthodontic appliances, fixed Streptococcus mutans Tooth demineralization

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beaty Dent

    RECRUITING

    Tirana, Albania, 1001, Albania

  • Happy Dent

    NOT_YET_RECRUITING

    Tirana, Albania, 1001, Albania

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