New hope for kidney stone patients: safer pain relief after surgery?
NCT ID NCT05100017
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two drugs—methocarbamol and oxybutynin—to see which works better for pain and discomfort caused by a ureteral stent placed after kidney stone surgery. About 126 adults aged 18 to 80 who have the surgery will take one of the study drugs along with standard pain medicines. The goal is to find a treatment with fewer side effects that still effectively eases stent-related symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 126 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Sep 2021
- Expected to finish
-
Dec 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 80 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Men and women between age 18-80 years who are diagnosed with stones who undergo ureteroscopy and ureteral stent placement. 2. Patients who consent to the procedure will be randomized in 1:1 fashion by RedCAP either to the methocarbamol or oxybutynin arm. All patients will receive standard of care diclofenac, tamsulosin, and pyridium for pain control plus one of the study drugs. 3. Willing to take only diclofenac (or tramadol for patients with contraindication to diclofenac), phenazopyridine, and acetaminophen for post stent placement discomfort. 4. Willing to sign the Informed Consent Form. 5. Able to read, understand, and complete patient questionnaires, pain texts, and medication diary. Exclusion Criteria: 1. Active, symptomatic urinary tract infection. 2. Non-stone related ureteral obstruction or stricture. 3. Procedural trauma or significant retained stone burden that could significantly contribute to patient discomfort. 4. Spinal cord injuries (sensory loss due to injury). 5. Non-stone related voiding dysfunction requiring supplemental bladder drainage tubes for more than 24 hours post operatively. 6. Chronic opioid usage for pain. 7. Members of vulnerable patient populations.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Kidney calculi are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Northwestern University
Chicago, Illinois, 60611, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a single drug dose curb opioid side effects after kidney stone surgery?
- Three ways to clear a blocked kidney: which works best?
- Kidney stone surgery without a hospital stay: can it be done safely?
- Two routes to clear bladder stones: which surgery works better?
- Muscle therapy may restore strength in dialysis patients
- Can software make hospital pharmacists faster and safer?