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Diabetes drug metformin may affect aging differently depending on your body

NCT ID NCT04264897

First seen Apr 24, 2026 · Last updated May 20, 2026 · Updated 3 times

Summary

This study looked at whether the diabetes drug metformin can slow aging in people without diabetes. Researchers wanted to see if the drug works differently depending on how sensitive a person is to insulin. Over 12 weeks, 101 healthy adults took either metformin or a placebo. The goal was to measure changes in insulin sensitivity, blood sugar control, and cell energy (mitochondria) to understand who might benefit most from metformin as an anti-aging treatment.

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Contacts and locations

Locations

  • University of Oklahoma Health Sciences Center, Oklahoma Shared Clinical and Translational Resources

    Oklahoma City, Oklahoma, 73104, United States

  • University of Wisconsin-Madison

    Madison, Wisconsin, 53705, United States

Conditions

Explore the condition pages connected to this study.