Can a blood test predict your risk of dying from metabolic disease?

NCT ID NCT04194372

Knowledge-focused Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is collecting blood samples and health data from 10,000 hospitalized patients with metabolic diseases like diabetes, obesity, or metabolic syndrome. Researchers will analyze genetic and other markers to create a personalized risk profile for death. The goal is to improve prediction of mortality in this group, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this could lead to better ways to predict which patients with metabolic diseases are at highest risk of death, helping doctors personalize care.
What could go wrong: This is an observational study, not a treatment trial. It will not directly improve health, and the risk profile may not be accurate for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 10,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2019

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

patients with pathologies associated with metabolic disease

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diabetic: antecedent - treatment - or glycemia\> = 1.26 g / dl - or HbA1C\> = 6.5% and or * Obese: BMI\> = 30 and or * Metabolic syndrome defined AND * Patient having given written consent to participate in the study or collection of the consent of the witness * Social insured patient (excluding AME) * Patient willing to comply with all procedures of the study and its duration AND Patient also presenting a pathology among: * Cardiology: * Coronary patient(history of myocardial infarction, coronary bypass, or coronary angioplasty or stenosis greater than 50% on an epicardial vessel documented on coronary angiography) * Patient with systolic or diastolic heart failure * Patient with atrial fibrillation * Patient with aortic stenosis (Vmax\> 2.5 m / s) * Patient with high blood pressure * neurology: * ischemic stroke * intracerebral hemorrhage * transient ischemic attack * diabetology: * Obesity without diabetes * Diabetes T2 * T1 diabetes * Monogenic Diabetes / MODY * African Diabetes * Diabetes secondary to pancreatopathy / liver cirrhosis * Diabetes post transplantation / post immunotherapy * Diabetes associated with Steinert's disease * hepatology: hepatological pathology * nephrology: nephrology Exclusion Criteria: * Unscheduled hospitalization less than 3 months old * Ongoing treatment : * Cytotoxic chemotherapy * Radiotherapy * HIV and / or HCV and / or active HBV infection * OMS score\> = 2 * Pregnant woman

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder metabolic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metabolic disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

3 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Can a blood test predict your risk of dying from metabolic disease?

What the study statuses mean