New, less invasive tooth treatments for kids show promise
NCT ID NCT05336682
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two simpler procedures called Lesion Sterilization and Tissue Repair (LSTR) against the standard root canal treatment (pulpectomy) for infected baby molars in 66 children. One LSTR method cleaned the root canals, while the other only removed the top pulp and placed an antibiotic paste. The goal was to see if these less invasive options could work as well as the standard treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- triple antibiotic paste with propylene glycol
- What this could lead to
- If successful, these simpler procedures could offer effective, less invasive alternatives to standard root canal treatment for children's baby teeth.
- What could go wrong
- This is a small, single-center trial with only 66 children. The results may not apply to all kids or other teeth, and long-term success is not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
66 people
The number who actually took part.
- Started
-
Sep 2022
- Finished
-
May 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
4 to 8 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Molars should be restorable. * Mandibular second primary molars with deep caries, vital carious pulp exposure, irreversible pulpitis. * Mobility: Non or grade I. * Radiographic signs of minimal external root resorption. Exclusion Criteria: * Children with known allergy to the agents used. * Children with infective endocarditis. * Refusal of participation. * Unable to attend follow-up visits.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Pulpitis - irreversible are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cairo University
Cairo, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New study tests which root canal cleaning method hurts less
- New Tooth-Saving materials put to the test against standard treatment
- New dental numbing method could spare kids from needle pain
- Alcohol may weaken dental anesthesia, new study suggests
- Vitamin d may soothe root canal pain, small trial hints
- New dental cement could save Kids' teeth without root canals