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Can a Life-Saving transplant leave hidden scars on a Child's mind?

NCT ID NCT07766304

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study looks at children aged 6 to 8 who had a stem cell transplant at least two years ago to treat a primary immunodeficiency—a genetic condition that weakens the immune system. Researchers will use standardized tests and interviews to measure the children's thinking skills, attention, memory, and emotional well-being, as well as how they function socially. The goal is to understand the long-term psychological and cognitive effects of this demanding treatment, which are not well known in this specific group of children.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Allogeneic hematopoietic stem cell transplantation (a procedure where a child receives healthy stem cells from a donor to rebuild their immune system)
What this could lead to
If successful, this could reveal how stem cell transplants affect children's thinking, emotions, and social life years later, guiding better support and follow-up care.
What could go wrong
This is a small pilot study with only 30 children, so findings may not apply to all. It observes outcomes but does not test a new treatment, so it cannot change how transplants are done directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Children between 6 and 8 years old who have received allogeneic hematopoietic stem cell transplantation for primary immunodeficiency for at least 2 years followed in the pediatric Immunohematology department of Necker Hospital (Assistance Publique-Hôpitaux de Paris).

Ages

6 to 8 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who underwent allogeneic transplantation for a primary immunodeficiency at Necker Hospital, regardless of the genetic diagnosis, and at least 2 years post Allogeneic hematopoietic stem cell transplantation. * Chronological age at the time of evaluation between 6 years and 8 years 11 months. * Holders of parental authority and children or adolescents or adults' patients informed and consenting to participate in the study Exclusion Criteria: * Child transplanted for a condition other than the primary immunodeficiency or at a different center. * Presence of an associated acquired or genetic neurological condition, independent of the PID, likely to significantly impair cognitive development. * Severe uncorrected sensory impairment (auditory or visual) rendering the cognitive assessment uninterpretable. * Refusal to participate by the child or those with parental authority. * Child not fluent in French or not proficient enough in French to complete the cognitive tests and questionnaires. * Profound intellectual disability.

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Conditions

The condition(s) this trial relates to.

inborn error of immunity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Allogeneic hematopoietic stem cell transplantation Primary immunodeficiencies

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hôpital Necker-Enfants Malades

    Paris, 75015, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.