Blood test may boost colorectal cancer screening in underserved communities

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Persons, aged 45 to 75 years old 2. Not up-to-date with screening, defined based on an existing electronic health record (EHR)-based flag that indicates absence of FIT within the last 12 months, colonoscopy within the last 10 years, sigmoidoscopy within the last 5 years or multi-target stool DNA (Cologuard) test within 3 years. 3. Attending primary care visits during the 2 months of recruitment. According to routine practice, screening status will be confirmed by primary care providers as part of routine visits. 4. Being provided the informed consent form. Exclusion Criteria: 1. Personal history of colorectal cancer (CRC), adenomas, or other related cancers. 2. Prior history of colorectal surgery 3. Family history of CRC, defined as having one or more first-degree relative (parent, sibling, or child) diagnosed with CRC at any age. 4. Up-to-date with colorectal cancer screening, defined as: * Fecal occult blood test (FOBT) or FIT within the last 12 months * FIT-DNA (Cologuard) or FIT-RNA (Colosense) test within 3 years * cfDNA (Shield) within the last year * CT colonography within the last 5 years * Sigmoidoscopy within the last 5 years * Colonoscopy within the last 10 years 5. Abnormal FIT, FOBT, cfDNA, FIT-DNA, or FIT-RNA test within the last 3 years. 6. Personal history of any of the following high-risk conditions for colorectal cancer: * Inflammatory Bowel Disease (IBD), including chronic ulcerative colitis (CUC) and Crohn's disease * Familial adenomatous polyposis (FAP) * Other hereditary cancer syndromes including but not limited to: * Hereditary non-polyposis colorectal cancer syndrome (HNPCC) or "Lynch Syndrome", Peutz-Jeghers Syndrome, MUTYH Polyposis (MAP), Familial Adenomatous Polyposis (FAP), Cowden's Syndrome, Juvenile Polyposis, Serrated Polyposis Syndrome 7. Uninsured patients will be excluded because of inability to ensure follow up. Because of recently expanded Medi-Cal eligibility, exclusions due to insurance are expected to be minimal.