Can a common laxative beat the standard prep for colon cancer screening?
NCT ID NCT06666556
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This trial compares two bowel-cleansing agents—lactulose and polyethylene glycol (PEG)—to see which provides a cleaner colon for colonoscopy. About 450 adults aged 18–79 scheduled for a screening colonoscopy will be randomly assigned to one of the two preparations. The study measures cleansing quality using the Boston Bowel Preparation Scale and tracks side effects like nausea and bloating to determine which option is more effective and better tolerated.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- lactulose or polyethylene glycol (PEG) as a bowel preparation agent before colonoscopy
- What this could lead to
- If lactulose works better, it could offer a more tolerable and effective option for cleaning the bowel before a colonoscopy, potentially improving screening quality.
- What could go wrong
- This is a Phase 4 trial comparing two existing agents, so the difference may be small. Side effects like nausea or bloating are possible with either preparation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
449 people
The number who actually took part.
- Started
-
Jul 2024
- Finished
-
Aug 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 79 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* Inclusion Criteria: * Patients with indication for colonoscopy in our coloproctology service * Both women and men * Patients within an age range of 18-79 years * Patients who agree having a colonoscopy and who sign the informed consent to participate in the protocol Exclusion Criteria: * Patients under 18 or over 80 years old * All patients that won´t like to participate in the protocol or won´t sign the informed consent * Pregnant women * Patients with a medical record of colonic resection, ostomy status, severe cardiopulmonary and renal diseases, major psychiatric disorders, therapeutic colonoscopy or any contraindications for colonoscopy * Non compliance with the colonic preparation regimen * Active bleeding during the procedure * Patients with a known diagnosis of colorectal cancer
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Antigüo Hospital Civil de Guadalajara "Fray Antonio Alcalde"
Guadalajara, Jalisco, 44200, Mexico
-
IMSS Hospital General Regional 220 "José Vicente Villada"
México, Toluca de Lerdo, 50150, Mexico
-
Nuevo Hospital Civil de Guadalajara "Juan I. Menchaca"
Guadalajara, Jalisco, 44340, Mexico
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