New Long-Acting numbing shot could ease pain after major abdominal surgery
NCT ID NCT07667439
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a long-acting numbing drug (liposomal bupivacaine) can reduce pain for up to 72 hours after open upper abdominal surgery. 148 adults having liver, stomach, or pancreatic surgery will get either the long-acting drug plus standard numbing, or standard numbing alone. The goal is to see if the long-acting version provides better and safer pain relief.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- liposomal bupivacaine plus bupivacaine hydrochloride
- What this could lead to
- If it works, this could provide a longer-lasting, safer way to manage pain after major abdominal surgery, reducing the need for strong painkillers.
- What could go wrong
- This is a small, early-stage trial (148 people) at one hospital. The benefit may be small or not apply to all surgeries, and there is a risk of side effects like nausea or dizziness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 148 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients scheduled for elective open upper abdominal surgery, including open liver, gastric and pancreatic surgery. 2. Patients receiving general anesthesia with tracheal intubation. 3. Aged from 18 to 80 years old. 4. Patients with American Society of Anesthesiologists (ASA) physical status class Ⅰ-Ⅲ. 5. Patients who can understand the trial content, are willing to strictly follow the clinical research protocol and complete the trial, and voluntarily sign the informed consent form. Exclusion Criteria: 1. Pregnant or lactating women. 2. Patients complicated with severe primary diseases of the lung, liver, kidney, cardiovascular system and hematopoietic system. 3. Bleeding tendency or coagulation dysfunction, defined as international normalized ratio (INR) ≥ 1.4, activated partial thromboplastin time \> 38 s, or platelet count \< 80×10⁹/L. 4. Patients with aggravated cardiac diseases (complex congenital heart disease, heart failure and valvular disease) or pulmonary insufficiency. 5. Skin infection at the puncture site for erector spinae plane block (ESPB). 6. Previous history of neurological or psychiatric diseases, with inability to read, understand and communicate. 7. Current obstructive or restrictive pulmonary disease. 8. Patients with BMI greater than 30 kg/m². 9. Drug abuse, long-term regular use of analgesics, or allergy to the study drugs. 10. Patients who refuse to provide informed consent. 11. Those enrolled in other randomized controlled trials simultaneously or with other conditions unsuitable for participation in this trial.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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the Second Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China
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