Can diet and exercise before pregnancy reduce baby fat?
NCT ID NCT03146156
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a healthy eating (Mediterranean diet) and exercise program started before pregnancy could help obese women lose 5-7% of their weight and improve health for both mother and baby. Researchers enrolled 99 women who had a previous baby and were planning another pregnancy within two years. The goal was to see if this lifestyle change could reduce fat in newborns and improve the mother's metabolism.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Lifestyle intervention (Mediterranean diet and exercise)
- What this could lead to
- If successful, this approach could help break the cycle of obesity by improving health in mothers and reducing fat in newborns.
- What could go wrong
- This is a small, early-stage study with only 99 participants. Results may not apply to all women, and lifestyle changes can be hard to maintain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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99 people
The number who actually took part.
- Started
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Mar 2017
- Finished
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Aug 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: All subjects will have had by the time of randomization at 3 months postpartum: 1. Planning another pregnancy within the next 24 months 2. Planning to deliver at Tufts medical center during their next pregnancy 3. A previous full-term singleton pregnancy (gestational age \> 37 weeks) 4. 18 to 40 years of age at the time of enrollment into the study 5. Vaginal or cesarean delivery 6. Normal glucose tolerance or gestational diabetes (GDM), but without evidence of postpartum diabetes as defined by a 75 g 2-hr oral glucose tolerance test (OGTT) 7. Normal blood pressure or mild preeclampsia but normal postpartum blood pressure 8. Bottle or breast feeding 9. Normal thyroid function (determined by TSH concentration in blood), normal cell blood count and normal kidney and liver functions. Lipid profile with triglyceride levels not higher than 400 mg/dl (fasting) and LDL levels less than 180 mg/dL 10. No clinical signs or symptoms of cardiovascular disease or any other disease or condition that may contraindicate participation in exercise training (i.e. COPD, severe asthma, orthopedic abnormalities) 11. Using contraception Exclusion criteria: 1. Pre or post-delivery diabetes 2. Post-delivery hypertension requiring medication 3. asthma requiring more than occasional use of a sympathomimetic inhaler, but not chronic inhaled steroids 4. Inflammatory bowel disease 5. Need for assisted reproductive technologies to become pregnant 6. Medical or obstetrical contraindication to the defined exercise program or diet 7. Tobacco, excessive alcohol use (greater than 2 drinks/day) or illicit drug use 8. Eating disorders such as bulimia 9. Gastric surgery to lose weight including banding or bypass procedures 10. Any psychological or psychiatric condition which may impair participation in the lifestyle intervention program 11. Multiple pregnancy 12. HIV, or hepatitis B or C 13. If a LIPP subject becomes pregnant prior to 16 weeks after randomization before the weight- loss phase for the lifestyle intervention is completed or a control subject becomes pregnant before the 3 month postpartum randomization, i.e. no baseline measurement.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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MetroHealth Medical Center
Cleveland, Ohio, 44109, United States
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Pennington Biomedical Research Center
Baton Rouge, Louisiana, 70808, United States
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Tufts Medical Center
Boston, Massachusetts, 02111, United States
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