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Could licorice help fight gum disease? new study says maybe

NCT ID NCT07422883

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a licorice extract gel could improve the results of deep cleaning for people with stage II periodontitis (moderate gum disease). Fifty patients were split into two groups: one got standard deep cleaning alone, and the other got deep cleaning plus licorice gel applied to the gum pockets twice a week for six weeks. The goal was to see if the gel reduced gum inflammation and lowered levels of a key inflammatory marker called interleukin-6.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
licorice extract gel (5% glycyrrhizin)
What this could lead to
If it works, this could point toward a natural, low-cost gel to improve gum health after standard deep cleaning.
What could go wrong
This is a small, early-stage study with only 20 treated patients. The results may not apply to everyone, and licorice gel is not a replacement for professional dental care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Feb 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with Stage II Periodontitis (mainly horizontal bone loss with maximum probing depth ≤ 5 mm and with 3-4 mm clinical attachment loss). * Age range (30 - 50) years. * Good compliance with the plaque control instructions following initial therapy. * Availability for follow up and maintenance program. Exclusion Criteria: * Smoking. * Systemic diseases which could influence the outcome of the therapy (According to Cornell Medical Index-Health Questionnaire). * Pregnant and lactating females. * Vulnerable groups of patients' e.g (prisoners, disabled patients and decisionally impaired individuals).

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Interleukin-6

Contacts and locations

Locations

  • Mansoura university

    Al Mansurah, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.