Timing of leucine supplements may boost muscle in seniors
NCT ID NCT06567665
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at when older men should take leucine supplements to best build muscle after exercise. Ten healthy men aged 65-75 will take leucine either with a meal or between meals after exercising. Researchers will measure how much new muscle protein is made to find the optimal timing.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Leucine (a dietary supplement, an essential amino acid)
- What this could lead to
- If it works, this could point toward simple dietary strategies to help older adults maintain muscle mass and prevent frailty.
- What could go wrong
- This is a very small, early-stage study with only 10 healthy men aged 65-75. Results may not apply to women, less healthy people, or those who exercise regularly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 10 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2024
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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65 to 75 years
- Sex
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Male participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male, 65-75 years of age * BMI 18-28 kg/m2 * Non smoker * Not performing regular resistance type exercise * Participant is willing and able to give informed consent for participation in the study Exclusion Criteria: * A BMI \<18 or \>28 kg·m-2 * Active cardiovascular disease: uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt or recent cardiac event * Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial) * Respiratory disease including pulmonary hypertension or chronic obstructive pulmonary disease (COPD) * Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes (treated and untreated), inborn/ congenital errors of metabolism (e.g. phenylketonuria (PKU), galactosaemia) * Active inflammatory bowel disease * Acute infection * Acute or chronic renal disease * Malignancy (or history of malignancy with 5 y) * Recent steroid treatment (within 6 mo), or hormone replacement therapy * Coagulopathy * Musculoskeletal or neurological disorders * Known allergies to any of the product ingredients * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Nottingham
RECRUITINGNottingham, Nottinghamshire, NG7 2UH, United Kingdom
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