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Ketone drink may boost muscle repair after workouts
NCT ID NCT06769100
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether drinking a ketone supplement can increase muscle protein synthesis (muscle repair and growth) after resistance exercise in 48 healthy young adults. Researchers compared the effects of the ketone drink alone, with whey protein, or with plain water. The goal was to see if ketones could enhance the muscle-building response to exercise and protein.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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48 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy adult female or male participants who are 18-40 years of age (inclusive) BMI \>18.5 and \<30.0 kg/m2 * Moderately active (i.e., ≥ 1 session of lower-body weightlifting /week for the previous 2 months). * Has maintained stable use of medication and supplements (which are not limited by the exclusion criteria), stable dietary and lifestyle habits, and stable body weight, for the last 3 months prior to screening and agree to maintain them throughout the study. * Be willing to entirely avoid alcohol consumption 48hr prior to the experimental test day. * Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures. Exclusion Criteria: * Females who are lactating or pregnant * Females using third-generation oral contraceptives (including: Desogen®, Ortho-Cept, Ortho-Cyclen, Ortho Tri-Cyclen) as these are known to affect protein metabolism in females. * Individuals with metabolic disorders including: Type I or Type II diabetes * Individuals with a history of thrombosis / cardiovascular disease * Individuals who use of anticoagulants * Individuals with musculoskeletal / orthopedic disorders * Individuals with knee injuries (i.e., ACL injuries). * Individuals who have used tobacco products within the last 6 months * Individuals with a history of neuromuscular problems * Chronic usage of medications known to modulate skeletal muscle metabolism (i.e. corticosteroids, hormone replacement therapy (HRT), and over-the-counter supplements including creatine monohydrate) in the last 6 months. * Individuals with allergies to milk proteins (whey or casein). * Individuals with lactose intolerance * Individuals with Phenylketonuria (PKU) * Previous participation in amino acid tracer studies. * Adherence to a vegetarian or vegan diet * Current use of ketone supplements or adherence to a ketogenic diet * Individuals who train more than ≥ 5 sessions of lower-body weightlifting /week for the previous 4 months
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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McGill University
Montreal, Quebec, H2W 1S4, Canada
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Other studies related to the condition(s) this trial covers.
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