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Knot or clip? study tests best way to seal the appendix after removal

NCT ID NCT07281612

Knowledge-focused Sponsor: Punjab Health Care Commission Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed trial looked at 190 people having laparoscopic appendix removal. It compared closing the appendix stump with a hand-tied knot versus a plastic clip. The goal was to see which method leads to fewer problems like infection or slow bowel recovery within 15 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If one method proves better, it could guide surgeons on the safest way to close the appendix stump, reducing complications after surgery.
What could go wrong
This is a small, early-phase trial (190 people) comparing two common techniques, so results may not be definitive or apply to all patients. Neither method is new or groundbreaking.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

190 people

The number who actually took part.

Started

Mar 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 10 to 70 years * Either sex * Clinical diagnosis of acute appendicitis with Alvarado score \>6 * ASA physical status I-III * Planned laparoscopic appendectomy Exclusion Criteria: * Patient request for open appendectomy * Complicated appendicitis (perforation, appendicular abscess, or appendicular mass) * Local or diffuse peritonitis * Friable or necrotic appendix base * Pelvic inflammatory disease

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Conditions

The condition(s) this trial relates to.

appendicitis ileus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Appendicectomy

Contacts and locations

Locations

  • AIMS

    Muzaffarabad, AJK/Punjab, 60000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.