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Breath of relief: ketamine or magnesium mist may stop Post-Surgery sore throat

NCT ID NCT07381036

Prevention Sponsor: Sohag University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether inhaling ketamine or magnesium sulfate before surgery can prevent the sore throat that often follows general anesthesia with a breathing tube. 150 adults having elective surgery will be randomly assigned to receive one of these treatments or a placebo. The goal is to see which works better at reducing pain and discomfort in the throat after the operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketamine and magnesium sulfate (nebulized)
What this could lead to
If successful, this could provide a simple, low-cost way to prevent sore throat after surgery with general anesthesia.
What could go wrong
This is a small, early-stage trial with no phase designation. The results may not apply to all surgeries or patients, and side effects like sedation or nausea are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age from 18 to 65 years old. * Both sexes. * American Society of Anesthesiologists (ASA) physical status I-II. * Elective surgery requiring GA with endotracheal intubation. \- Exclusion Criteria: * Surgery involves the oral cavity, nasopharynx, larynx, and neck regions. * Surgery requires prone position. * Surgery lasted more than 3 hours. * History of preoperative sore throat, common cold. * Anticipated difficult airway. * Any known allergies to study drugs. * Recent non-steroidal anti-inflammatory drugs use. * Pregnancy.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative sore throat Prevention of post operative sore throat

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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