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Can a simple inhaled drug soothe Post-Surgery sore throats?

NCT ID NCT07746115

Prevention Sponsor: Aswan University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Sep 03, 2026 · Updated 4 times

Summary

This trial tests whether inhaling a low dose of ketamine before anesthesia can prevent the sore throat that often follows breathing tubes used during surgery. Adults aged 18-65 scheduled for elective surgery will receive either 25 mg, 50 mg, or a placebo mist before anesthesia. Researchers will track how many participants develop a sore throat and its severity over the first 24 hours after surgery, aiming to find the smallest effective dose with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nebulized ketamine (25 mg or 50 mg) inhaled before anesthesia
What this could lead to
If effective, this could establish a low-dose, non-invasive way to prevent postoperative sore throat, improving patient comfort and satisfaction after surgery.
What could go wrong
The trial is relatively small and early, and the lower dose may not match the higher dose's effectiveness. Ketamine can cause side effects like nausea, dizziness, or hallucinations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

195 people

The number who actually took part.

Started

Aug 2026

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 65 years. * American Society of Anesthesiologists (ASA) physical status I or II. * Scheduled for elective surgery under general anesthesia requiring endotracheal intubation. * Able to provide written informed consent. * Willing to comply with all study procedures and follow-up assessments. Exclusion Criteria: * Known hypersensitivity or allergy to ketamine. * Pre-existing sore throat, hoarseness, or significant upper airway pathology. * Current upper respiratory tract infection. * Anticipated difficult airway or more than one intubation attempt. * Surgery involving the upper airway, oral cavity, pharynx, larynx, or maxillofacial region. * Severe cardiovascular disease or uncontrolled hypertension. * Severe respiratory disease. * Pregnancy or breastfeeding. * History of psychiatric illness or psychosis. * Chronic opioid use or regular use of analgesic or anti-inflammatory medications. * Inability to communicate postoperative symptoms or complete study assessments.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative sore throat

Contacts and locations

Locations

  • Ayman Mohamady Eldemrdash

    Aswān, Aswan Governorate, 81528, Egypt

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