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Ketamine may offer better pain relief during biopsies than standard sedation

NCT ID NCT07040163

Symptom relief Sponsor: CAMC Health System Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether ketamine, combined with midazolam, can reduce pain better than the usual fentanyl and midazolam combination for patients undergoing biopsies or drainage procedures. About 276 adults will be randomly assigned to one of the two sedation methods. Researchers will track pain scores, side effects, and patient satisfaction to see if ketamine improves the experience without raising risks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketamine
What this could lead to
If ketamine works better, it could offer a safer, more comfortable sedation option for common interventional radiology procedures.
What could go wrong
This is an early-phase trial with 276 participants, so results may not apply to everyone. Ketamine can cause side effects like hallucinations or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

276 people

The number who actually took part.

Started

Mar 2025

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Planned to undergo image-guided bone biopsy, lung biopsy, or percutaneous drainage * Eligible to receive ketamine or fentanyl sedation * Any sex/gender, any race * Aged 18-89 Exclusion Criteria: * Pregnant/lactating * Incarceration * Currently taking an opioid agonist/antagonist * Food consumed in past 6-8 hours * Allergies to drugs used in the study * Lacks mental capacity for reporting pain scores * Hypotension or respiratory failure precluding fentanyl sedation * Uncontrolled hypertension precluding ketamine sedation * Condition for which hypertension would be a concern * Schizophrenia

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIOPSY Drainage procedure Interventional radiology Sedation

Contacts and locations

Locations

  • CAMC Memorial

    Charleston, West Virginia, 25304, United States

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