Watching the Brain's blood supply as anesthesia takes hold
NCT ID NCT04288869
First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time
Summary
Researchers observe how blood flow to the brain changes when adults receive general anesthesia for radiology procedures or orthopedic surgery. They use ultrasound, near-infrared light, and brain wave monitoring to measure blood flow velocity, oxygen levels, and brain activity at three points: before anesthesia, before breathing tube placement, and after mechanical ventilation starts. The study also tracks these measurements when blood pressure drops and during treatment. The goal is to understand the relationship between blood pressure, brain perfusion, and brain function during anesthesia.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If researchers map how brain blood flow and oxygen change during anesthesia, doctors may learn to adjust blood pressure targets to protect the brain during surgery.
- What could go wrong
- This observational study cannot prove that any monitoring method prevents brain injury. It only records measurements in 68 adults, so the findings may not apply to other patients or anesthesia drugs.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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68 people
The number who actually took part.
- Started
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Jan 2021
- Finished
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Oct 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study involves major patients who benefit from intraoperative hemodynamic optimization with norepinephrine (as noradrenaline tartrate) for maintaining blood pressure under general anesthesia during an interventional neuroradiology procedure or orthopedic surgery.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Major patients (≥ 18 years old) * Eligible for an interventional radiology procedure or orthopedic surgery under general anesthesia. * Patients who expressed their non-opposition to participation in this research Exclusion Criteria: * Patients under the age of 18. * Patient opposed to participation in the protocol * Pregnant woman * Patient under judicial protection measure * Patient without affiliation to a social security scheme-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AP-HP, Lariboisière Hospital, Department of Anesthesiology and Intensive Care
Paris, 75010, France
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