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Which works better for bone infections: cleaning or replacing hardware?

NCT ID NCT07669714

Disease control Sponsor: Antalya Health Sciences University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study compares two ways to treat early infections that happen after bone fracture surgery: cleaning the area and keeping the original hardware (DAIR) versus removing and replacing the hardware. Researchers will track 75 patients to see which method leads to better infection-free bone healing. The goal is to find the best approach to stop the infection and help the bone heal properly.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Debridement, antibiotics, and implant retention (DAIR) or implant removal/replacement
What this could lead to
If successful, this could help doctors choose the best treatment for early fracture infections, improving healing and reducing repeat infections.
What could go wrong
This is a small, retrospective study (75 people) that looks back at past cases, so it cannot prove cause and effect. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

94 people

The number who actually took part.

Started

Apr 2026

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study planned to include over 18 years old patients who underwent internal fixation after fracture, had a fistula and/or sinus tract, or purulent drainage with incision dehiscence, at least 2 positive deep tissue cultures or at least 3 positive soft tissue cultures, whose findings started early (6 weeks), and who underwent DAIR or implant removal/replacement due to fracture-related infection.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * internal fixation after fracture * presence of fistula and/or sinus tract or purulent drainage with dehiscence at the incision site * at least 2 positive deep tissue cultures or at least 3 positive soft tissue cultures * early onset of symptoms (6 weeks) * DAIR or implant removal/replacement due to fracture-related infection Exclusion Criteria: * Under 18 years old patients * prosthetic joint infection * only conservative treatment applied * pathological fracture due to primary bone tumor * simultaneous infection foci in the same extremity * fracture-related infection not confirmed by international consensus criteria * poor reduction after internal fixation * inappropriate or inadequate internal fixation * radiological images less than 1 year old * findings starting late (after 6 weeks)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Debridement Fracture related infection Implant removal/replacement Implant retention Orthopedic surgery

Contacts and locations

Locations

  • University of Health Sciences, Antalya Training and Research Hospital

    Antalya, Turkey (Türkiye)

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