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Could a blood pressure cuff boost brain recovery after stroke?

NCT ID NCT05906602

Knowledge-focused Sponsor: University of Illinois at Chicago Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a technique called ischemic conditioning, where a cuff around the thigh briefly restricts blood flow, to see if it can improve brain activity and leg function in people who had a stroke. Twenty participants with a stroke at least six months prior completed two sessions—one with real blood flow restriction and one with a sham (fake) version. The goal was to measure changes in brain signals and motor control, not to provide a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

May 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Single, stroke \> 6 months since onset * Residual hemiparetic gait deficits (e.g., abnormal gait pattern) Exclusion Criteria: * Lesions affecting the brainstem or cerebellum * Other neurological disorders that may interfere with motor function * Unhealed decubiti, persistent infections that may interfere with ability to perform test procedures * Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE\<21)), which could impede the understanding of the purpose of procedures of the study * Botulinum toxin (Botox) treatments to the lower limb within the past 6 months * Pregnant women * Contraindications to transcranial magnetic stimulation (TMS) or ischemic conditioning (IC) (Listed below) TMS General Exclusion Criteria: * Previous adverse reaction to TMS * Skull abnormalities or fractures * Concussion within the last 6 months * Unexplained, recurring headaches * Implanted cardiac pacemaker * Metal implants in the head or face * History of seizures or epilepsy * Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants) * Current pregnancy IC General Exclusion Criteria: * History of thrombosis (i.e., blood clots) including venous thrombosis or deep vein thrombosis (DVT). * Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., open wounds in the leg, bruising, nerve damage, etc.) * Peripheral arterial grafts in the lower extremity * History of uncontrolled hypertension * History of peripheral vascular disease or hematological disease

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

Contacts and locations

Locations

  • University of Illinois Chicago

    Chicago, Illinois, 60612, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.