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A steroid inside the breathing tube could soothe Post-Surgery throat pain

NCT ID NCT07760272

Symptom relief Sponsor: B.P. Koirala Institute of Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 25, 2026 · Updated 3 times

Summary

This trial tests whether placing a steroid called dexamethasone inside the breathing tube's cuff can prevent or lessen sore throat, cough, and hoarseness after laparoscopic gallbladder removal. About 40 adults having this surgery will be randomly assigned to receive either the steroid or a saltwater solution in the tube cuff. Researchers will then track throat symptoms for 24 hours after surgery to see if the steroid offers better comfort.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexamethasone (a corticosteroid) placed inside the breathing tube cuff during surgery
What this could lead to
If it works, this simple, low-cost approach could ease throat discomfort and improve recovery for many people after surgery with a breathing tube.
What could go wrong
This is a small, early-stage trial, so results may not apply broadly. The drug could still cause side effects, and the benefit over standard care is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient aged 18-65 years. * Either sex * ASA physical status I or II * Mallampatti grade I and II. * Patient scheduled for elective laparoscopic cholecystectomy * Patient requiring general anesthesia with endotracheal intubation * Expected duration of surgery \<2 hours. * Patients /patient's family member who provide written informed consent. Exclusion Criteria: * Refusal for consent * Mallampati grade III or IV * More than two attempts at endotracheal intubation. * Reintubation * Use of bougie or stylet for intubation. * Evidence of traumatic intubation (blood stained secretions or blood on ETT cuff) * Preexisting sore throat, hoarseness of voice or upper respiratory tract infection. * Patient receiving systemic or inhaled steroids. * Known case of allergy to dexamethasone.

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Conditions

The condition(s) this trial relates to.

Cough Hoarseness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative sore throat, cough, hoarseness

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.