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Could a simple change in breathing tube cuffs reduce Post-Surgery throat pain?

NCT ID NCT07315490

Symptom relief Sponsor: PAEC General Hospital, Islamabad Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using lignocaine (a numbing medicine) instead of air to inflate the cuff of a breathing tube can lower the chance of sore throat, cough, and hoarseness after surgery. About 80 adults having general anesthesia will be randomly assigned to receive either air or lignocaine in the cuff. Researchers will measure cuff pressure and throat symptoms for 24 hours after surgery to see which approach works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Xylocaine (lignocaine)
What this could lead to
If it works, this could offer a simple, low-cost way to reduce throat pain and other side effects after surgery, especially in settings where pressure monitors are not available.
What could go wrong
This is a small, early-stage study with only 80 participants, so results may not apply to everyone. The benefit over air may be small or not clinically meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

80 people

The number who actually took part.

Started

Aug 2025

Expected to finish

Jan 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA (American Society of Anaesthesiologists) I and II * Male/Female * Age group 18 - 55 years * Patient undergoing surgery under general anesthesia. * Patients undergoing surgery in supine/ Trendelenburg position. Exclusion Criteria: * ASA III and IV * Patients with preoperative history of cough or sore throat * Patients undergoing nose, throat, or airway surgery. * Patients with history of allergic diseases * Patient with known pulmonary disease * Patients in whom more than 1 attempt on intubation is done * Patients who may need postoperative ventilation.

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Conditions

The condition(s) this trial relates to.

Cough Hoarseness pharyngitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative sore throat, cough, hoarseness

Contacts and locations

Locations

  • Liaquat

    Islamabad, Federal Capital, 44800, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.