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Can retraining the Brain's food cues help teens with anorexia?

NCT ID NCT05763849

Disease control Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two psychological treatments for adolescents aged 12-18 with anorexia nervosa: a new approach called Interoceptive Exposure Therapy (IE) versus standard Family Based Therapy (FBT). IE helps teens face food-related fears by pairing feared foods with positive experiences, while parents learn to support this at home. The goal is to see which therapy better helps teens reach a healthy body weight and reduces the impairment caused by the eating disorder, with follow-up for one year after treatment ends.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Interoceptive Exposure Therapy (behavioral therapy)
What this could lead to
If this therapy works, it could offer a new, more effective psychological treatment for adolescents with anorexia nervosa, helping them achieve and maintain a healthy weight.
What could go wrong
This is a relatively small trial (120 participants) comparing two behavioral therapies, so results may not apply to all patients. The therapy requires active participation and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 12-18 * Speak English * Permission from pediatrician or equivalent to receive outpatient care * Clinically significant restriction of food intake by EDA-5 or evidence of persistent food avoidance from patient or guardians * Evidence of the inability to maintain greater than minimally low body weight based on BMI for age percentiles and growth trajectories Exclusion Criteria: * Comorbid psychotic or bipolar disorder * Active suicidal ideation * Current substance dependence * Psychiatric medication initiated or dosage changes \<2 weeks from baseline * Major medical illness (e.g., diabetes mellitus, Crohn's disease, etc.)

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Conditions

The condition(s) this trial relates to.

anorexia nervosa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anorexia nervosa

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Psychiatry, Eating and Weight Disorders Program

    RECRUITING

    New York, New York, 10028, United States

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