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What makes insulin stop working? scientists investigate healthy people

NCT ID NCT07255807

Knowledge-focused Sponsor: University of Copenhagen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 18, 2026 · Updated 2 times

Summary

This study looks at why some healthy adults develop insulin resistance, a condition where the body doesn't use insulin well. Researchers will ask 80 participants to either reduce physical activity for 14 days or eat a high-fat diet for 3 days. They will then measure changes in insulin sensitivity and look at blood and tissue samples to find molecular clues. The goal is to better understand how lifestyle and biology interact, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jun 2038

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 25-55 years * Body Mass Index (BMI): 18-30 kg/m² * Healthy (no diagnosed chronic diseases) * Able and willing to comply with study procedures Exclusion Criteria: * Smoking or nicotine use, current or within the past 5 years * Alcohol intake exceeding 10 units per week * Hemoglobin A1c (HbA1c) \> 48 mmol/mol (indicative of diabetes or prediabetes) * Chronic diseases (e.g., cardiovascular disease, diabetes, etc.) * Chronic medication use, including hormonal treatments * High physical activity levels (more than 3 hours per week of moderate to vigorous exercise) * Pregnancy or within 3 months postpartum * Breastfeeding or within 3 months of cessation * Abnormal routine blood markers (as defined in lab screening) * Blood donation within the past 2 months

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Conditions

The condition(s) this trial relates to.

Insulin Resistance Sedentary Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Insulin sensitivity/resistance Metabolic health

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • August Krogh Building

    RECRUITING

    Copenhagen, 2100, Denmark

More trials for these conditions

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