Scientists watch inflammation change skin and mood in real time

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy * 18-40 years-old * Consent form signed * Having a Swedish personal identification number (personnummer) Exclusion Criteria: * Non-fluent in Swedish * Unable to read * Unable or unwilling to provide informed consent * BMI below 18.5 or above 25 kg/m2 * Smoking * Excessive alcohol consumption * Pregnancy or breastfeeding * Positive on drug screening * Current somatic disease including skin disease affecting the measurement areas * Current depression, anxiety, sleep disturbances or other psychiatric illnesses * Abnormal blood analyses: abnormal clinical levels in blood cell counts, hemoglobin, sodium, potassium, chloride, calcium, phosphate, creatinine, blood urea nitrogen, uric acid, glucose, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, bilirubin, thromboplastin time and partial thromboplastin time * High-sensitivity C-reactive protein \> 10 mg/L. * History of cardiovascular, pneumological, immune disease * Moderate viral or bacterial infection in the past two weeks * Severe and/or long-term COVID-19: positive SARS-CoV-2 PCR-test or antigen-test and/or history of symptoms since February 2020 indicative of infection with SARS-CoV-2 (fever, cough, sore throat, runny or blocked nose, nausea, muscle pain, shortness of breath), which was of high intensity and/or of long duration (≥ 8 weeks). * Recent vaccination (within previous two weeks) * Abnormal cardiovascular measurements * Current or previous cancer * Any concomitant medication other than contraceptives (14 days prior to the start and throughout the study period) * Shift work or irregular sleep-wake cycle (within 14 days of the study period) * Needle anxiety or blood phobia * Invisible veins in the antecubital area of the arms or very difficult blood sampling (self-reported or experienced during screening). * Previous participation in a study involving administration of LPS