New combo therapy shows promise for kids with deadly brain tumors
NCT ID NCT04049669
First seen Jan 11, 2026 · Last updated May 01, 2026 · Updated 13 times
Summary
This study tests whether adding the drug indoximod to standard chemotherapy and radiation can help children aged 3 to 21 with certain brain cancers (glioblastoma, medulloblastoma, ependymoma, or DIPG) live longer without their cancer growing. Indoximod works by blocking a natural immune-suppressing pathway, potentially helping the body's immune system fight the tumor more effectively. The trial enrolls up to 130 participants and measures how long the cancer is controlled and overall survival.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Augusta University, Georgia Cancer Center
Augusta, Georgia, 30912, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Emory University, Children's Heathcare of Atlanta
Druid Hills, Georgia, 30322, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
Conditions
Explore the condition pages connected to this study.