Simple home treatments may boost leg strength after amputation
NCT ID NCT07664995
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests two non-invasive treatments—ischemic conditioning (using a blood pressure cuff to briefly restrict blood flow) and neuromuscular electrical stimulation (mild electrical pulses to trigger muscle contractions)—in 24 adults with above- or below-knee amputation. Participants will do one or both treatments at home every other day for two weeks. Researchers will measure changes in walking speed, muscle strength, and movement patterns to see if these therapies can improve function and mobility.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ischemic conditioning (blood pressure cuff) and neuromuscular electrical stimulation
- What this could lead to
- If it works, this could point toward a simple home-based therapy to improve walking and muscle strength after leg amputation.
- What could go wrong
- This is a very small early trial (24 people) with no placebo group, so results may not apply widely. The interventions are short-term (2 weeks) and may not produce lasting benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 24 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Older than 18 years old * History of unilateral transfemoral or transtibial amputation * Able to ambulate independently without the use of aids (i.e., walking cane) * Able to walk at least 6 minutes continuously without stopping. * Has a safe residuum with no open wounds on either the residual or intact limb * Has a prosthetic limb with materials that are sound and safe to withstand the mobility requirements of the study Exclusion Criteria: * Younger than 18 years old * Inability to give informed consent * Neurological disorder such as multiple sclerosis that affects gait * Currently pregnant (or intend to become pregnant while participating in study) * Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. open wounds in the leg) * History of uncontrolled hypertension * History of heart failure * Implanted electrical device such as a pacemaker or defibrillator * Head injury within the previous 6 months * Seizure disorder * History of thrombosis * History of sickle cell trait * History of genetic disease that impacts gait (e.g. cerebral palsy, muscular dystrophy).
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Illinois Chicago
Chicago, Illinois, 60607, United States
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