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Timing of eye surgery under the microscope: early or late?

NCT ID NCT05145491

Knowledge-focused Sponsor: Jaeb Center for Health Research Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study compares immediate surgery versus waiting for vision to worsen in people with an epiretinal membrane (a thin layer of scar tissue on the eye's surface). It includes 400 adults with relatively good vision (20/40 or better) who have symptoms like blurring or distortion. The goal is to see which timing leads to better vision over 3 years and to learn more about how the condition progresses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * Age ≥ 45 years * E-ETDRS visual acuity 20/40 or better (≥69 letters) o ERM must be thought to be the primary cause of vision loss * ERM meeting the following criteria, according to the investigator * ERM is not secondary to another condition * Symptoms of visual loss and/or distortion (in the opinion of the investigator, the ERM is contributing to the participant's symptoms); either new or worsening in the past 24 months * Epiretinal membrane involving or altering the central 3 mm of the macula on OCT * Distortion within the central subfield due to ERM on OCT * Immediate vitrectomy not required (investigator and participant are willing to wait at least 4 weeks to see if vision remains stable without having to proceed to vitrectomy) * No known medical problems that will be a contraindication to surgery Key Exclusion Criteria: * History of retinal vascular disease * History of vitreous hemorrhage if vitreous hemorrhage is thought to have caused the ERM o History of vitreous hemorrhage is permitted provided the vitreous hemorrhage did not cause the ERM in the investigator's opinion * History of inflammatory disease unless mild and completely resolved at least one year prior to randomization * History of diabetic macular edema (DME), retinal vein occlusion (RVO), or uveitis (except mild uveitis that resolved \>1 year prior to randomization) * Prior intraocular surgery (except uncomplicated cataract extraction) * Cataract extraction within prior 3 months * Laser or cryosurgical retinopexy within one month of randomization * Pneumatic retinopexy within one year of randomization * Current untreated retinal tear or detachment o A previously treated retinal tear with up to one disc diameter radius of subretinal fluid is permitted * Macular hole * Degenerative lamellar macular hole o ERM foveoschisis ("tractional" lamellar hole) is permitted * Vitreomacular traction within 1,500 microns of foveal center * Central serous chorioretinopathy * Nonproliferative diabetic retinopathy or worse (DR severity \>20)

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Conditions

The condition(s) this trial relates to.

preretinal fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Epiretinal membrane

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    48 sites in 2 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Austin Research Center for Retina

    RECRUITING

    Austin, Texas, 78705, United States

  • Baylor College of Medicine, Baylor Eye Physicians and Surgeons

    RECRUITING

    Houston, Texas, 77030, United States

  • Cascade Medical Research Institute, LLC

    RECRUITING

    Springfield, Oregon, 97477, United States

  • East Bay Retina Consultants, Inc.

    RECRUITING

    Oakland, California, 94609-3028, United States

  • Elman Retina Group, P.A.

    RECRUITING

    Baltimore, Maryland, 21237, United States

  • Florida Retina Institute, James A. Staman, MD, PA- Jacksonville

    RECRUITING

    Jacksonville, Florida, 32216, United States

  • Hilton Head Retina Institute

    RECRUITING

    Hilton Head Island, South Carolina, 29926, United States

  • Illinois Retina Associates SC - Oak Park Site

    RECRUITING

    Oak Park, Illinois, 60304, United States

  • Johns Hopkins University

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • Joseph E. Humble and Raymond Haik PTRS DBA Eye Assoc of Northeast Louisiana

    RECRUITING

    West Monroe, Louisiana, 71291-4452, United States

  • Joslin Diabetes Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Kent W. Small, MD, AMC

    RECRUITING

    Glendale, California, 91203-1971, United States

  • Loma Linda University

    RECRUITING

    Loma Linda, California, 92354, United States

  • Macula Retina Vitreous Institute

    RECRUITING

    Torrance, California, 90503, United States

  • Mayo Clinic Arizona

    RECRUITING

    Scottsdale, Arizona, 85259, United States

  • Mid-America Retina Consultants, P.A.

    RECRUITING

    Overland Park, Kansas, 66211, United States

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Ophthalmology Ltd.

    RECRUITING

    Sioux Falls, South Dakota, 57108, United States

  • Pittsburg Clinical Trial Consortium

    RECRUITING

    Sewickley, Pennsylvania, 15143, United States

  • Raj K. Maturi, M.D., P.C.

    RECRUITING

    Indianapolis, Indiana, 46290, United States

  • Regents of the University of California, Davis, DBA University of California, Davis

    RECRUITING

    Sacramento, California, 95817, United States

  • Retina Associates of Michigan

    RECRUITING

    Grand Blanc, Michigan, 48439, United States

  • Retina Associates of Western NY, P.C.

    RECRUITING

    Rochester, New York, 14620-4655, United States

  • Retina Consultants of Texas

    RECRUITING

    Bellaire, Texas, 77401, United States

  • Retina Research Institute, LLC

    RECRUITING

    St Louis, Missouri, 63128-1729, United States

  • Retina Vitreous Associates, Northern California Retina Vitreous Assoc Medical Group, Inc.

    RECRUITING

    Mountain View, California, 94040-4123, United States

  • Retina Vitreous Center

    RECRUITING

    Edmond, Oklahoma, 73013-9791, United States

  • Retina-Vitreous Consultants, Inc.

    RECRUITING

    Monroeville, Pennsylvania, 15146, United States

  • Retina-Vitreous Surgeons of Central NY, PC

    RECRUITING

    Liverpool, New York, 13088, United States

  • Retinal Consultants of San Antonio

    RECRUITING

    San Antonio, Texas, 78240, United States

  • Rush University Medical Center

    RECRUITING

    Chicago, Illinois, 60612, United States

  • SEASHORE RETINA LLC DBA Retina Specialists of Tampa

    RECRUITING

    Wesley Chapel, Florida, 33544, United States

  • Salehi Retina Institute Inc.

    RECRUITING

    Huntington Beach, California, 92647-8693, United States

  • Sarasota Retina Institute

    RECRUITING

    Sarasota, Florida, 34239, United States

    Contact Email: •••••@•••••

  • South Tyneside and Sunderland NHS Trust

    RECRUITING

    Sunderland, Tyne and Wear, SR29HP, United Kingdom

  • Southeast Retina Center, P.C.

    RECRUITING

    Augusta, Georgia, 30909, United States

  • Spokane Eye Clinical Research, PLLC

    RECRUITING

    Spokane, Washington, 99204, United States

  • Texas Retina Associates

    RECRUITING

    Lubbock, Texas, 79424, United States

  • The Curators of the University of Missouri

    RECRUITING

    Columbia, Missouri, 65201-5276, United States

  • The Retina Group of Washington

    RECRUITING

    Reston, Virginia, 20190, United States

  • The Trustees of the University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Thomas Eye Group

    RECRUITING

    Sandy Springs, Georgia, 30328, United States

  • UIC - Department of Ophthalmology and Visual Sciences

    RECRUITING

    Chicago, Illinois, 60612, United States

  • University of Kansas Medical Center Research Institute, Inc.

    RECRUITING

    Prairie Village, Kansas, 66208, United States

  • University of North Carolina at Chapel Hill

    RECRUITING

    Chapel Hill, North Carolina, 27517, United States

  • Valley Eye Physicians and Surgeons

    RECRUITING

    Ayer, Massachusetts, 01432, United States

    Contact Email: •••••@•••••

  • Vanderbilt Eye Institute

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • Verum Research LLC

    RECRUITING

    Eugene, Oregon, 97401, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.