Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a 2-Minute chat reverse acute stress? new trial aims to find out

NCT ID NCT06482567

Symptom relief Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a short intervention called iCOVER, designed to help people quickly regain focus and calm after an acute stress reaction. The intervention takes just 60-120 seconds and can be given by peers or medical staff. Researchers will enroll 450 adults in an emergency department who show signs of distress or dissociation, and compare iCOVER to usual care or simple reassurance. The goal is to see if iCOVER improves thinking and functioning right after the stressful event.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
iCOVER (a brief behavioral intervention using steps: Identify, Connect, Offer commitment, Verify facts, Establish order, Request action)
What this could lead to
If it works, this could provide a quick, easy-to-use tool for peers or medical staff to help someone snap out of an acute stress reaction and think clearly again.
What could go wrong
This is an early efficacy trial with 450 participants, so results may not apply broadly. The intervention is very brief and may not work for everyone or in all stressful situations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 450 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥ 18 years and ≤ 50 years of age (if age not known, appears to be) * In the emergency department as a patient or loved one of a patient * If a patient, anticipated to be discharged to home from the emergency department after evaluation * Exhibiting visible signs of distress Richmond Agitation and Sedation Scale ((RASS) (+1 to +3)) or dissociation (awake and alert but reduced responsiveness) * Likely able to speak English Exclusion Criteria: * Known pregnancy * Prisoner or in custody * Known history of psychosis or bipolar disorder * Known or suspected drug intoxication * Known history of substantial cognitive impairment * Known or suspected altered mental status due to traumatic brain injury * Known active psychosis, suicidal ideation, or homicidal ideation * Unable to use both hands (e.g. due to sprain) * Any other history or condition that would, in the site investigator's judgement, indicate that the individual would very likely be non-compliant with the study or unsuitable for the study (e.g. might interfere with the study, confound interpretation, or endanger participant)

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Acute stress reaction are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

acute stress disorder dissociative disorder injury post-traumatic stress disorder Stress Disorders, Traumatic, Acute

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute stress reaction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cooper University Health Care

    RECRUITING

    Camden, New Jersey, 08103, United States

  • Henry Ford Health System

    RECRUITING

    Detroit, Michigan, 48202, United States

  • McLean Hospital, Harvard Medical School

    ACTIVE_NOT_RECRUITING

    Belmont, Massachusetts, 02478, United States

  • University of Massachusetts Chan Medical School

    RECRUITING

    Worcester, Massachusetts, 01655, United States

  • Washington University, St. Louis

    RECRUITING

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.