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Could a simple blood injection ease your jaw pain?

NCT ID NCT05883982

Symptom relief Sponsor: Hospital of the Ministry of Interior, Kielce, Poland Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether injecting a concentrate of the patient's own blood proteins (I-PRF) into the jaw joint could reduce pain and improve jaw opening in people with temporomandibular joint (TMJ) disorders. 49 adults with TMJ pain or limited jaw movement received the injection. The study measured pain levels and how wide they could open their mouth before and after treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
I-PRF (injectable platelet-rich fibrin, made from the patient's own blood)
What this could lead to
If it works, this could offer a simple, natural injection to ease jaw pain and improve movement for people with TMJ disorders.
What could go wrong
This is a small, completed Phase 2 trial with no control group, so results may not be definitive. Benefits may vary, and risks include injection-site reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

49 people

The number who actually took part.

Started

Jun 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age over 18; * informed consent to participate in the study; * the possibility of discontinuing the current treatment of the temporomandibular joints; * generally accepted indications for injection therapy. Exclusion Criteria: * bleeding diathesis; * mental illness; * temporomandibular joint prosthesis; * temporomandibular joint ankylosis; * skin disease of the preauricular area of the affected side.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular joint disorders Temporomandibular joint pain

Contacts and locations

Locations

  • Department of Maxillofacial Surgery

    Kielce, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.