Could a simple blood injection ease your jaw pain?

NCT ID NCT05883982

Completed Symptom relief Sponsor: Hospital of the Ministry of Interior, Kielce, Poland Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether injecting a concentrate of the patient's own blood proteins (I-PRF) into the jaw joint could reduce pain and improve jaw opening in people with temporomandibular joint (TMJ) disorders. 49 adults with TMJ pain or limited jaw movement received the injection. The study measured pain levels and how wide they could open their mouth before and after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: I-PRF (injectable platelet-rich fibrin, made from the patient's own blood)
What this could lead to: If it works, this could offer a simple, natural injection to ease jaw pain and improve movement for people with TMJ disorders.
What could go wrong: This is a small, completed Phase 2 trial with no control group, so results may not be definitive. Benefits may vary, and risks include injection-site reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TEMPOROMANDIBULAR JOINT DISORDERS TEMPOROMANDIBULAR JOINT PAIN

Contacts and locations

Locations

Department of Maxillofacial Surgery

Kielce, Poland

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