Could a simple blood injection ease your jaw pain?
NCT ID NCT05883982
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether injecting a concentrate of the patient's own blood proteins (I-PRF) into the jaw joint could reduce pain and improve jaw opening in people with temporomandibular joint (TMJ) disorders. 49 adults with TMJ pain or limited jaw movement received the injection. The study measured pain levels and how wide they could open their mouth before and after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
I-PRF (injectable platelet-rich fibrin, made from the patient's own blood)
What this could lead to
If it works, this could offer a simple, natural injection to ease jaw pain and improve movement for people with TMJ disorders.
What could go wrong
This is a small, completed Phase 2 trial with no control group, so results may not be definitive. Benefits may vary, and risks include injection-site reactions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Department of Maxillofacial Surgery
Kielce, Poland